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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A case report described two patients, out of whom, a 76-year-old woman developed Listeria monocytogenes(L. monocytogenes) meningitis during immunosuppression therapy with prednisone, and a 73-year-old man developed L. monocytogenes meningitis during immunosuppression therapy with prednisone and methotrexate [routes, dosages and durations of treatments to reaction onset not stated].
This report describes a 76-year-old woman: The woman, who had been receiving therapy with prednisone for polymyalgia rheumatica, presented to the hospital with vomiting, disorientation and headache in 2009. Her co-morbidities included renal failure. At presentation, her temperature was 38.2°C. She opened her eyes upon application of a painful stimulus, localised symmetrically and made incomprehensible...
- Engelen-Lee J-Y, et al. Histopathology of Listeria meningitis. Journal of Neuropathology and Experimental Neurology 77: 950-957, No. 10, 1 Oct 2018. Available from: URL: http://doi.org/10.1093/jnen/nly077 - Netherlands