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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 63-year-old man in Germany, developed Takotsubo cardiomyopathy (TTC) during concurrent therapy with etomidate for anaesthesia and tranylcypromine for depression [routes not stated].
The man had a history of stress and recurrent depressive disorder, which needed in-patient treatment on a repeated basis. As his depressive episodes were refractory to various other medications in the past, he had been receiving electroconvulsive therapy (ECT). Other pre-existing conditions included obesity, latent arterial hypertension and nicotine abuse. A recently performed transthoracic echocardiographic study had shown good systolic LV function without wall motion abnormalities. Following ECT therapy, his depressive symptoms showed almost complete remission. As a maintenance...
- Kudling R, et al. Tako-Tsubo cardiomyopathy during a series of Electroconvulsive Therapy (ECT) applications: A case report, systematic literature research and discussion of specific risk factors. [German]. Fortschritte der Neurologie Psychiatrie 86: 699-710, No. 11, 2018. Available from: URL: http://doi.org/10.1055/a-0653-7063 [German; summarised from a translation] - GermanyCrossRefGoogle Scholar