- 17 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a study of 99 patients, who underwent genotypic drug resistance testing in South Korea (between October 2014 and April 2017), 9 men aged 30−56 years were described, who acquired resistance to integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) following treatment with elvitegravir or raltegravir for HIV-1 infection [dosages, routes and durations of treatments to reactions onsets not stated].
Patient A: A 44-year-old man, who was diagnosed with HIV-1 infection and who had been receiving raltegravir along with concomitant tenofovir disoproxil fumarate and emtricitabine, was included in a study. He subsequently underwent genotypic drug resistance test, which revealed acquaintance of INSTI-major mutation of Y143C. It was suspected that the exposure to...
- Jeong W, et al. Integrase Strand Transfer Inhibitor Resistance Mutations in Antiretroviral Therapy-Naive and Treatment-Experienced HIV Patients in South Korea. AIDS Research and Human Retroviruses 35: 213-216, No. 2, Feb 2019. Available from: URL: http://doi.org/10.1089/aid.2018.0213 - South KoreaCrossRefGoogle Scholar