- 43 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
An 82-year-old man developed late onset hepatitis B virus (HBV) reactivation following treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone, dexamethasone, etoposide, ifosfamide and carboplatin for diffuse large B-cell lymphoma (DLBCL), and pravastatin for dyslipidaemia.
The man presented with positive hepatitis B surface antigen (HBs-Ag) test. Prior to the current presentation, he had DLBCL, diabetes and dyslipidaemia. He had undergone treatment with 6 courses of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP therapy). Following the therapy, a complete remission was achieved. However, the disease relapsed. Therefore, he received treatment with 6 courses of rituximab, dexamethasone, etoposide, ifosfamide and...