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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a retrospective case series of patients treated between 1991 and 2018, six patients in their 30s−50s (four men and two women; including a 46-year-old man) [not all exact ages at reactions onsets stated] were described, who developed Graves' disease and Graves' orbitopathy (thyroid orbitopathy/thyroid eye disease) during treatment with alemtuzumab [Lemtrada] for multiple sclerosis. In two of the six patients, treatment with iodine-131 was also considered as a contributing factor in the development of Graves' orbitopathy [dosages and routes not stated; not all outcomes stated].
Case 1: The man in his mid-30s was diagnosed with multiple sclerosis (MS) at the age of 26-years. He had received treatment with interferon-beta-1a for MS. Then, at the age of 34-years, he had started...