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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 55-year-old man developed thrombocytopenia during treatment with heparin for left ventricular thrombosis.
The man in cardiogenic shock secondary to non-ischaemic cardiomyopathy presented for advanced care and heart transplant evaluation. Five days prior to presentation, he had been detected with a left ventricular thrombus, and he had started receiving treatment with unfractionated heparin [dosages and route not stated]. Upon admission, investigations revealed platelet count of 208 × 109/L. Over six days, the platelet count steadily decreased to a nadir of 72 × 109/L. A ventilation-perfusion scan studies revealed a high-intermediate likelihood for pulmonary embolism. However, venous duplex ultrasound did not show deep vein thrombosis in the lower extremities. He had an...