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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 70-year-old woman developed polyarticular gout and encephalopathy during treatment with furosemide for a right heart failure.
The woman had a history of alcohol-induced liver cirrhosis, chronic kidney disease, portopulmonary hypertension and paroxysmal atrial fibrillation requiring anticoagulation [specific drug not stated]. She was hospitalised in Australia for treatment of symptomatic iron deficiency anaemia, rectal bleeding, marked-dependent oedema and worsening exertional dyspnoea. During the hospitalisation, she was diagnosed with a right heart failure and transfused with two units of packed RBCs and also started receiving treatment with ferric carboxymaltose and IV infusion of furosemide [frusemide; dosage not stated]. The anticoagulation was stopped. She was started on...
- Lewis CS, et al. Polyarticular arthropathy and encephalopathy in a 70-year-old woman. BMJ Case Reports 11: No. 1, 13 Dec 2018. Available from: URL: http://doi.org/10.1136/bcr-2018-227058 - Australia