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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A case series described two men aged 45 and 57 years, respectively, who developed resistance to colistin during treatment of multi-drug resistant Acinetobacter baumannii infection. Additionally, the 45-year-old man developed worsening of renal function, and the 57-year-old man developed acute kidney injury during treatment with colistin.
Case 1: The 45-year-old man suffered a flame and flash burn from an explosion in a shed. The areas of burn included his neck, face, trunk and all four extremities representing a total body surface area (TBSA) of 38%. Prior to being transferred to the burn center, he was intubated. He did not have any inhalational injury on arrival. He was resuscitated. On post-burn day (PBD) 2, he was extubated. However, his respiratory function deteriorated...
- Saun TJ, et al. The Use of Intravenous and Inhaled Colistin Therapy during a Burn Center Outbreak of Multidrug-Resistant Acinetobacter baumannii. Journal of Burn Care and Research 39: 1029-1036, No. 6, Nov-Dec 2018. Available from: URL: http://doi.org/10.1097/BCR.0000000000000626 - CanadaPubMedGoogle Scholar