Reactions Weekly

, Volume 1739, Issue 1, pp 81–81 | Cite as


Various toxicities: 6 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a study, six patients [not all sexes stated] aged 38−67 years were described, who developed various toxicities, including allergic reactions, complaints in mouth, neutropenic fever, diarrhoea, nausea, leucopenia, hand-foot syndrome, abdominal cramps, thrombocytopenia, neutropenia, anorexia, fatigue, oral mucositis, stomatitis, fever or combinations thereof, during treatment with capecitabine for cancer [routes not stated].

Patient 1: A 50-year-old patient was initiated on capecitabine 1 000 mg/m2BID following various interventions for triple negative breast cancer (cT3N3M0). However, after cycle 1, the patient developed severe toxicity in the form of an allergic reaction, resulting in a swollen, red face, neutropenic fever, nausea, complaints in the mouth, diarrhoea and...


  1. Lunenburg CATC, et al. Diagnostic and therapeutic strategies for fluoropyrimidine treatment of patients carrying multiple DPYD variants. Genes 9: No. 12, 28 Nov 2018. Available from: URL: - Netherlands

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