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Reactions Weekly

, Volume 1739, Issue 1, pp 81–81 | Cite as

Capecitabine

Various toxicities: 6 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a study, six patients [not all sexes stated] aged 38−67 years were described, who developed various toxicities, including allergic reactions, complaints in mouth, neutropenic fever, diarrhoea, nausea, leucopenia, hand-foot syndrome, abdominal cramps, thrombocytopenia, neutropenia, anorexia, fatigue, oral mucositis, stomatitis, fever or combinations thereof, during treatment with capecitabine for cancer [routes not stated].

Patient 1: A 50-year-old patient was initiated on capecitabine 1 000 mg/m2BID following various interventions for triple negative breast cancer (cT3N3M0). However, after cycle 1, the patient developed severe toxicity in the form of an allergic reaction, resulting in a swollen, red face, neutropenic fever, nausea, complaints in the mouth, diarrhoea and...

Reference

  1. Lunenburg CATC, et al. Diagnostic and therapeutic strategies for fluoropyrimidine treatment of patients carrying multiple DPYD variants. Genes 9: No. 12, 28 Nov 2018. Available from: URL: http://doi.org/10.3390/genes9120585 - Netherlands

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© Springer Nature Switzerland AG 2019

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