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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a retrospective study, 7 patients (four women and three men) aged 44−77 years were described, who developed angioedema during treatment with olmesartan medoxomil, irbesartan, candesartan cilexetil, valsartan, telmisartan, fimasartan, eprosartan or lisinopril for hypertension [routes and frequencies not stated].
Case 1: A 77-year-old woman developed angioedema during treatment with olmesartan medoxomil, irbesartan and candesartan cilexetil for hypertension. The woman, who had a history of allergic rhinitis, had been receiving prednisolone for more than 12 months for multifocal pneumonia and rheumatic diseases. Additionally, she had been receiving losartan for high BP for the past several years and she had no particular symptoms. Subsequently, losartan was switched to...