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, Volume 1738, Issue 1, pp 189–190 | Cite as

Multiple drugs

Ocular surface disease secondary to drug intoxication leading to the worsening of the pre-existing primary open-angel glaucoma: 10 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a retrospective study of 10 patients, who were followed at centre national d'Ophtalmologie des Quinze-Vingts, Paris, France, between March 2016−May 2017, seven men and three women, aged 61−90 years, were described, who developed ocular surface disease (OSD) secondary to drug intoxication, which lead to the worsening of the pre-existing primary open-angel glaucoma (POAG) during treatment with bimatoprost, bimatoprost/timolol, brimonidine, carteolol, dorzolamide, dorzolamide/timolol, latanoprost, neomycin/dexamethasone, pilocarpine or travoprost [dose not stated]; some of the above medications had unspecified preservatives that contributed to the ADR's.

Case 1: A 74-year-old woman, who had POAG for 15 years, presented with blepharitis, hyperaemia 1+, oxford score of 2, and...


  1. Dubrulle P, et al. Influence of treating ocular surface disease on intraocular pressure in glaucoma patients intolerant to their topical treatments: A report of 10 cases. Journal of Glaucoma 27: 1105-1111, No. 12, Dec 2018. Available from: URL: - France

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