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, Volume 1737, Issue 1, pp 207–207 | Cite as

Multiple drugs

Fatal neutropenic enterocolitis caused by Stenotrophomonas maltophilia: case report: case report
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 28-year-old man developed fatal neutropenic enterocolitis caused by Stenotrophomonas maltophilia during treatment with azacitidine, beclometasone [beclomethasone dipropionate], busulfan, ciclosporin [cyclosporine A], cyclophosphamide, cytarabine, etoposide, meropenem, gemtuzumab-ozogamicin, methotrexate, methylprednisolone, mitoxantrone, mycophenolate mofetil, tacrolimus and vancomycin [routes not stated; not all dosages and indications stated].

The man, who had acute myeloid leukaemia, underwent peripheral blood stem cell transplantation (PBSCT). He received conditioning regimen included busulfan 12.8 mg/kg and cyclophosphamide 120 mg/kg. He also received ciclosporin and short-term methotrexate for GVHD prophylaxis; however, he developed grade I acute graft versus host...


  1. Kaito S, et al. Fatal neutropenic enterocolitis caused by stenotrophomonas maltophilia: A rare and underrecognized entity. Internal Medicine 57: 3667-3671, No. 24, 2018. Available from: URL: - Japan

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