Reactions Weekly

, Volume 1735, Issue 1, pp 159–159 | Cite as


Hypophysitis and various other toxicities: 3 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a case series, three patients (1 woman and 2 men) aged 51−75 years were described, of whom a 75 year-old man developed hypophysitis, adrenal insufficiency and hypogonadotrophic hypogonadism, a 68-year-old woman developed hypophysitis, panhypopituitarism, adrenal insufficiency and hypothyroidism, and a 51-year-old man developed hypophysitis, panhypopituitarism, adrenal insufficiency, hypogonadotrophic hypogonadism and hypothyroidism, during treatment with ipilimumab for metastatic melanoma [dosages, routes and durations of treatments to reactions onsets not stated; not all outcomes stated].

Case 1: The 75-year-old man, who had right ear melanoma metastatic to posterior cervical lymph nodes and lung, had received two cycles of ipilimumab therapy two years apart. Each...


  1. Wadhwa V. Ipilimumab Induced Hypophysitis: MRI Findings in a Series of 3 Cases. Journal of the Arkansas Medical Society 113: 270-272, No. 11, May 2017 - USAGoogle Scholar

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