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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a study, 9 patients (4 girls and 5 boys) aged 12−17 years were described, who developed chemotherapy-induced peripheral neuropathy during treatment with blinatumomab, bortezomib, brentuximab-vedotin, clofarabine, cytarabine, etoposide, fludarabine, procarbazine, topotecan or vincristine [dosages and routes not stated; not all durations of treatments to reactions onsets stated] for acute lymphoid leukaemia (ALL), neuroblastoma (NB), Hodgkin disease (HD), acute promyelocytic leukaemia (APL) or acute myeloid leukaemia (AML).
Patient 1: The 17-year-old boy, who had stage III ALL, received chemotherapy including vincristine and bortezomib. Eighteen days after the initiation of chemotherapy, he developed neuropathic pain in lower limb indicating chemotherapy-induced peripheral...
- Tomasello C, et al. Scrambler therapy efficacy and safety for neuropathic pain correlated with chemotherapy-induced peripheral neuropathy in adolescents: A preliminary study. Pediatric Blood and Cancer 65: e27064, No. 7, Jul 2018. Available from: URL: http://doi.org/10.1002/pbc.27064 - ItalyCrossRefPubMedGoogle Scholar