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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a retrospective non-comparative case series, 3 women and one man aged 65−91 years were described, who developed acute-onset postoperative endophthalmitis after off label use of moxifloxacin/triamcinolone [TriMoxi] at the end of cataract surgery.
Case 1: The 73-year-old woman presented with a 1-day history of pain, redness and decreased vision in the left eye. She had undergone a dropless cataract surgery 9 days prior to onset of symptoms. At the end of cataract surgery, she had receiveded transzonular intravitreal moxifloxacin/triamcinolone 0.2mL injection. On examination, her corrected distance visual acuity (CDVA) in the left eye was 20/80. Fibrin and cells in the anterior chamber, a well-centered intraocular lens (IOL) and dense vitritis were also noted. She underwent a...
- Kishore K, et al. Acute-onset postoperative endophthalmitis after cataract surgery and transzonular intravitreal triamcinolone-moxifloxacin. Journal of Cataract and Refractive Surgery 44: 1436-1440, No. 12, Dec 2018. Available from: URL: http://doi.org/10.1016/j.jcrs.2018.07.055 - USA