Reactions Weekly

, Volume 1733, Issue 1, pp 125–125 | Cite as


Secondary chondroblastic osteosarcoma, osteoblastic osteosarcoma and disseminated metastatic disease: 3 case reports
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A case report described three boys aged 9−14 years were described, who developed secondary chondroblastic or osteoblastic osteosarcoma following treatment with cyclophosphamide, etoposide or ifosfamide for medulloblastoma, germ cell tumour or anaplastic astrocytoma [routes not stated; not all dosages stated]. Out of these patients, the 9-year-old boy died due to disseminated metastatic disease, including the worsening of lung metastasis.

Case 1: An 11-year-old boy presented with pain in the left thigh persisting more than two months. He had developed medulloblastoma in the cerebellar vermis at 4 years of age. The treatment for the medulloblastoma consisted of tumour resection followed by radiotherapy and high-dose intensive chemotherapy. He received chemotherapy with...


  1. Shimatani A, et al. Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports. Molecular and Clinical Oncology 10: 153-158, No. 1, Jan 2019. Available from: URL: - JapanGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Personalised recommendations