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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 31-year-old woman developed Balint syndrome secondary to drug-induced posterior reversible encephalopathy syndrome (PRES) during treatment with tacrolimus for immunosuppression.
The woman, who had a history of familial pulmonary fibrosis, received elective double lung transplant. After transplantation surgery, she started receiving immunosuppression therapy comprising mycophenolate and tacrolimus 2.5mg every 12 hours [route not stated]. About nine days following the lung transplantation, she reported severe frontal headache with blurry vision and difficulty grasping objects in front of her. Physical examination showed a temperature of 98.7°F and a BP of 132/92mm Hg. She was alert and oriented to time, name and place. Ophthalmologic examination showed that the pupils were...
- Brown CH, et al. Ocular Dysfunctions Presenting in Tacrolimus-Induced Posterior Reversible Encephalopathy Syndrome: A Case Presentation. P M and R - The Journal of Injury, Function and Rehabilitation 10: 105-111, No. 1, Jan 2018. Available from: URL: http://doi.org/10.1016/j.pmrj.2017.07.079 - USACrossRefGoogle Scholar