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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, a 72-year-old woman developed drug-induced malignant arrhythmia (DIMA) during treatment with amiodarone [amiodarone hydrochloride], sotalol and moxifloxacin [moxifloxacin hydrochloride] and a 34-year-old man developed DIMA during treatment with azithromycin and fluconazole [not all the dosages, routes and time to reactions onsets stated].
Case 1: The woman was admitted to the emergency ICU because of chest tightness with loss of consciousness for 3 days. Emergency ECG revealed a prolonged QT interval. She was diagnosed with pulmonary infection, including community-acquired pneumonia. She started receiving treatment with IV moxifloxacin 0.4g once a day ivgtt1injection in sodium chloride as anti-infective treatment. On day 3, day 6 and day 8 after...