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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A tertiary single centre, prospective, observational cohort study, conducted between 01 July 2010 and 31 December 2015 described 9 patients (8 adult women and one neonate), who developed various toxicities following administration of warfarin or heparin [heparin sodium] as anticoagulants for mechanical heart valves or maternal exposure [dosages and duration of treatments to reactions onsets not stated; not all ages, sexes, routes and outcomes stated].
Patient 1: An 18-year-old pregnant woman had undergone double valve replacement (mitral and aortic). She received warfarin and IV heparin [unfractionated heparin] alternatively as anticoagulation therapy for mechanical heart valves. In gestation week 36, she underwent normal vaginal delivery. However, she returned to casualty...
- Kariv S, et al. Haemorrhage and other complications in pregnant women on anticoagulation for mechanical heart valves: A prospective observational cohort study. Cardiovascular Journal of Africa 29: 289-295, No. 5, Oct 2018. Available from: URL: http://doi.org/10.5830/CVJA-2018-029 - South AfricaCrossRefPubMedGoogle Scholar