Apixaban/serotonin uptake inhibitors/tacrolimus interaction
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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
* Drug interaction
A case series described two men (a 70-year-old man and a 60-year-old man). The 70-year-old man developed haemopericardium due to concomitant administration of apixaban and fluoxetine. The 60-year-old man developed haemopericardium due to concomitant administration of apixaban, sertraline and tacrolimus [not all dosages and route stated; not all durations of treatments to reaction onsets stated].
Case 1: A 70-year-old man, who was in United States, had a history of hyperlipidaemia, hypertension, stage 3 chronic kidney disease and solitary functioning kidney. He was hospitalised due to a complaint of chest pain and diagnosed with atrial fibrillation. He was discharged with oral apixaban 5mg twice daily as an anticoagulant therapy. Concomitantly, he had been...