- 38 Downloads
An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a study of 239 patients conducted between November 2017−May 2018, five patients (four men and one woman) [ages at the time of reaction onset not clearly stated] were described, who exhibited treatment failure secondary to emergence of resistance to asunaprevir/daclatasvir, ledipasvir/sofosbuvir, elbasvir/grazoprevir or asunaprevir/beclabuvir/daclatasvir during treatment of hepatitis C virus (HCV) infection [routes, dosages and duration of treatment to reactions onsets not stated].
Case 1: The man exhibited treatment failure secondary to emergence of resistance to asunaprevir/daclatasvir and ledipasvir/sofosbuvir: The man with HCV genotype 1b, presented at the age of 50 years. He was admitted for the treatment of HCV owning to previous treatment failure of various direct...