Reactions Weekly

, Volume 1732, Issue 1, pp 48–48 | Cite as


Disseminated aspergillosis: 5 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a retrospective study of patients with acute lymphoblastic leukaemia (ALL) between 1 July 2000 and 31 July2006 collected from AIEOP-BFM ALL 2000 study, five patients [2 boys; not all sexes stated] aged 3−16 years were described, who developed disseminated aspergillosis during treatment with prednisone, vincristine, daunorubicin, pegaspargase [PEG-asparaginase], dexamethasone, asparaginase [L-asparaginase], etoposide or cyclophosphamide for ALL. Eventually, 4 of the 5 patients died due to complication of aspergillosis [routes, dosages and durations of treatments to reactions onsets not stated; not all outcomes stated].

Patient 1: A 3-year-old boy was diagnosed with ALL and received treatment with prednisone, vincristine, daunorubicin and pegaspargase. Thereafter, he developed...


  1. Fischer J, et al. Surgical Implications for Diagnosis and Treatment of Intestinal Aspergillosis in Pediatric Patients with ALL. European Journal of Pediatric Surgery 28: 477-483, No. 6, Dec 2018. Available from: URL: - GermanyCrossRefPubMedGoogle Scholar

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