Reactions Weekly

, Volume 1732, Issue 1, pp 44–44 | Cite as


Clostridium difficile infections: 12 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a retrospective study of 14 pregnant women, 12 women aged 24−39 years were described, who developed Clostridium difficile infections following treatment with piperacillin/tazobactam, ciprofloxacin, cefepime, amoxicillin/clavulanic acid, azithromycin, cefixime, clindamycin, cefotaxime, benzylpenicillin, amoxicillin, ceftriaxone, ofloxacin or unspecified corticosteroids. Additionally, six of these 12 women received vancomycin or metronidazole during pregnancy for treating Clostridium difficile infections [dosages, routes, durations of treatments to reactions onsets and pregnancy outcomes not stated; not all outcomes stated].

Patient 1: A 32-year-old woman, who had pneumonia, received treatment with piperacillin/tazobactam [Tazocillin], ciprofloxacin and cefepime during...


  1. de Curraize C, et al. Variable spectrum of disease and risk factors of peripartum Clostridium difficile infection: report of 14 cases from French hospitals and literature review. European Journal of Clinical Microbiology and Infectious Diseases 37: 2293-2299, No. 12, Part A, Dec 2018. Available from: URL: - France

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© Springer Nature Switzerland AG 2018

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