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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, five patients (4 women and 1 man), aged 25−42 years, were described, who developed hyperalgesia during treatment with morphine (two patients), methadone and hydromorphone (one patient), oxycodone and hydromorphone (one patient) and oxycodone (one patient) for pain due to vaso-occlusive episodes (VOEs). Additionally, a patient developed desaturation events and somnolence while receiving morphine, and another patient experienced desaturation events attributed to hydromorphone and oxycodone and vivid dreams attributed to ketamine [durations of treatments to reactions onset not stated; not all routes stated].
Patient 1: A 25-year-old woman, who had sickle cell disease, was admitted due to VOEs. Prior to admission, she had been receiving treatment with morphine...
- Palm N, et al. Low-Dose Ketamine Infusion for Adjunct Management during Vaso-occlusive Episodes in Adults with Sickle Cell Disease: A Case Series. Journal of Pain and Palliative Care Pharmacotherapy 32: 20-26, No. 1, Mar 2018. Available from: URL: http://doi.org/10.1080/15360288.2018.1468383 - USACrossRefGoogle Scholar