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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
* Drug overdose
In a study of 61 patients with impaired driving, who underwent blood drug screening between 2015 and 2017 in the USA, five men aged 32−60 years were described, who developed constricted pupils, unresponsiveness, sluggish speech, slurred speech, unconsciousness, slow speech, sleepiness or glassy eyes following overdose of buprenorphine, oxycodone/paracetamol, morphine or methadone. Out of these five patients, two patients also had an abuse of oxycodone [time to reactions onsets not stated, not all routes, dosages and outcomes stated].
A 38-year-old man became unconscious, unresponsive and developed constricted pupils following abuse of oxycodone at an overdose: The man's vehicle was found stopped in the middle of an intersection. He was unresponsive and was going...
- Tiscione NB, et al. Carfentanil in impaired driving cases and the importance of drug seizure data. Journal of Analytical Toxicology 42: 476-484, No. 7, 01 Sep 2018. Available from: URL: http://doi.org/10.1093/jat/bky026 - USA