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In a case series, six patients (3 boys and 3 girls) aged 5−15 years were described, who developed eye allergy in the form of ocular and periocular manifestations (diagnosed between April 2014 to December 2017) to atropine [atropine sulfate] eye drops for retardation of progressive myopia. Out of these 6 patients, 5 patients received atropine formulations containing chlorobutanol [chlorbutol] as preservative which also contributed to the ocular allergy.
Patient 1: A 12-year-old girl developed eye allergy following treatment with atropine 1% eye drops [Bell Pino] containing chlorobutanol as preservative once at night. She had myopia for which treatment with atropine eye drops was initiated. After 7 months, she developed ocular symptoms like itching, burning, conjuctival congestion and discharge, swelling of eyelid, periocular redness, periocular skin erosion and follicular reaction. Diagnosis of eye allergy in the form of ocular and periocular manifestations was made. Treatment with...