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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, 4 patients (3 men and 1 woman) aged 56−68 years were described, who developed sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) during treatment with oxaliplatin, rituximab, dexamethasone and cytarabine for lymphoma [routes and dosages not stated].
Case 1: The 56-year-old man, who had diffuse large B-cell lymphoma, received 8 cycles of R-CHOP therapy consisting of rituximab, cyclophosphamide, vincristine [Oncovin] and doxorubicin [hydroxy doxorubicin] with partial response. He then received 3 cycles of salvage chemotherapy with R-DHAO regimen, which consisted of rituximab, dexamethasone, cytarabine and oxaliplatin, and underwent an autologous transplantation following conditioning regimen. He presented 7 days after transplant with anasarca...
- Bernichon E, et al. Sinusoidal obstruction syndrome/veno-occlusive disease complication in lymphoma patients treated with oxaliplatin-based regimen: A case series report. Current Research in Translational Medicine 66: 107-110, No. 4, Nov 2018. Available from: URL: http://doi.org/10.1016/j.retram.2018.01.004 - FranceCrossRefPubMedGoogle Scholar