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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 31-year-old man had lack of effect of diazepam, midazolam and propofol for muscle spasms in tetanus. He also developed myalgia following an off label use of rocuronium bromide [rocuronium] for muscle spasms in tetanus.
The man presented for lockjaw. He had been a metamfetamine [methamphetamine]1abuser (snorting) for 5 years. He sustained multiple injuries including a left calcaneal fracture while riding a motorcycle under the influence of metamfetamine and alcohol. Subsequently, he was hospitalised and underwent detoxification with activated charcoal. He received tetanus immune globulin [antitetanus serum] and tetanus toxoid injection. Thereafter, he underwent a series of debridement and open reduction with screw fixation and cerclage wiring of the left calcaneus, with...
- Enriquez CAG, et al. Rocuronium for control of muscle spasms in a tetanus patient with chronic methamphetamine use disorder. BMJ Case Reports 2018: 10 Apr 2018. Available from: URL: http://doi.org/10.1136/bcr-2018-224391 - Philippines