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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 32-year-old man developed pulmonary nocardiosis and pulmonary Mycobacterium avium infection during treatment with azathioprine, infliximab and prednisolone for ileocecal Crohn's disease [routes and dosages not stated].
The man had a long-standing history of ileocecal Crohn's disease. Following benign course of Crohn's disease, he suffered a severe flare-up of Crohn's disease with abdominal pain and diarrhoea during the previous year. This was treated with prednisolone and azathioprine over 3 months. He was also treated with infliximab for the previous 2 months. Cotrimoxazole was started for Pneumocystisprophylaxis; however, his adherence to this prophylactic therapy was low. Following initiation of infliximab, the abdominal complaints resolved, but he continued to lose...
- Weber M, et al. Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy. Zeitschrift fur Gastroenterologie 56: 569-572, No. 6, Jun 2018. Available from: URL: http://doi.org/10.1055/a-0614-2871 - GermanyCrossRefPubMedGoogle Scholar