Reactions Weekly

, Volume 1710, Issue 1, pp 208–208 | Cite as


Various toxicities: 2 case reports
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a case report, a 28-year-old woman developed placental delayed villous maturation (DVM) and impaired placenta blood flow due to chorionic thrombosis following methadone maintenance therapy during pregnancy. The woman delivered a stillborn female fetus at 39 weeks of gestation. The cause of fetus death was considered as hypoxic-ischaemic encephalopathy along with chronic fetal methadone intoxication, placental DVM and impaired placenta blood flow due to chorionic thrombosis following in-utero exposure of methadone [time to reactions onsets not stated].

The woman was receiving methadone maintenance therapy at 80 mg/day during the pregnancy. Her therapy with methadone was discontinued 15 days before delivery. Prior to the delivery, the woman was admitted because fetal movements...


  1. Montanari E, et al. Toxicological and histological analyses for a stillborn delivered by a mother under methadone maintenance therapy. Forensic Toxicology 36: 514-524, No. 2, Jul 2018. Available from: URL: - Italy

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© Springer Nature Switzerland AG 2018

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