Reactions Weekly

, Volume 1710, Issue 1, pp 43–43 | Cite as


Various toxicities: 2 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

Two patients (one man and one woman) in their 60s [exact ages at the time of reactions onsets not stated] were described, of whom the woman developed severe pain and retropharyngeal/prevertebral abscess following treatment with docetaxel and cetuximab. The man developed severe pain, bilateral pneumonia, Staphylococcus aureus infection with thoracic and lumbar paravertebral abscesses following treatment with cisplatin, fluorouracil [5-FU] and cetuximab.

Case 1: The woman was diagnosed with hypo-pharynx carcinoma in December 2014. Initially, she received definitive radio-chemotherapy. After six months, she received palliative chemotherapy with docetaxel per week combined with cetuximab [routes and dosages not stated]. After receiving four cycles, cetuximab dose was modified to...


  1. Gerlach C, et al. Severe Pain Due to Paraspinal Abscess Formation in Two Patients with Squamous-Cell Carcinoma of the Head and Neck after Multimodal Treatment Including Cetuximab. Oncology Research and Treatment 41: 395-398, No. 6, Jun 2018. Available from: URL: - GermanyCrossRefPubMedGoogle Scholar

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