, Volume 33, Issue 12, pp 1245–1253 | Cite as

Economic and Quality-of-Life Implications of Non-Alcoholic Fatty Liver Disease

  • Zobair M. YounossiEmail author
  • Linda Henry
Leading Article


Non-alcoholic fatty liver disease (NAFLD) is a very common chronic liver disease worldwide, is on the rise following the trend of increasing prevalence of obesity, is the second most common indication for liver transplantation, and is an important cause for hepatocellular carcinoma. Despite the increasing recognition of NAFLD as an important chronic liver disease, little has been published on the economic and health-related quality of life (HR-QOL) impact of NAFLD. We reviewed the current literature related to the economics and HR-QOL of NAFLD and found that increased costs and decreased HR-QOL were associated with NAFLD.


Obstructive Sleep Apnea NASH Epworth Sleepiness Scale Alcoholic Liver Disease Medical Expenditure Panel Survey 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Compliance with Ethical Standards

This study was approved through our institutional review board and is in full compliance with all ethical standards regarding secondary data research. In addition, no external funding was received for this study; only internal funds were used. Zobair Younossi, MD is a consultant to Abbvie, Gilead, BMS, Intercept and GSK. Linda Henry PhD has any conflicts of interest to report.

Author contributions

Both authors shared responsibility for the development and writing of this manuscript. Dr. Zobair Younossi is the guarantor for the overall content.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of MedicineInova Fairfax HospitalFalls ChurchUSA
  2. 2.Betty and Guy Beatty Center for Integrated Research, Inova Health SystemFalls ChurchUSA
  3. 3.Center for Outcomes Research in Liver DiseasesWashington DCUSA

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