Cost of Illness in Colorectal Cancer: An International Review
- 378 Downloads
Given the current—and increasing—pressure to limit expenditure on health care provision in many countries, a better understanding of the cost burden of colorectal cancer is needed. Cost-of-illness studies and reviews thereof can be a useful tool for analysing and critically evaluating the cost-related development of colorectal cancer, and they highlight important cost drivers.
A systematic review was conducted from 2002 to 2012 to identify cost-of-illness studies related to colorectal cancer, searching the Medline, PubMed, Science Direct, Cochrane Library and the York CRD databases.
Among the 10 studies (from France, the US, Ireland and Taiwan) included in the review, 6 studies reported prevalence-based estimates and 4 studies focussed on incidence-based data. In the studies included in the review, long-term costs for colorectal cancer of up to $50,175 per patient (2008 values) were estimated. Most of the studies in the review showed that the initial and terminal phases of colorectal cancer care are the most expensive, with continuing treatment being the least costly phase. One study also highlighted that stage I CRC disease was the least costly and stage III the most costly of all 4 stages, due to the high cost impact of biological agents.
This review has highlighted a trend for rising costs associated with CRC, which is linked to the increasing use of targeted biological therapies. COI studies in colorectal cancer can identify specific components and areas of care that are especially costly, thereby focussing attention on more cost-effective approaches, which is especially relevant to the increased use of biological agents in the field of personalised medicine. COI studies are an important tool for further health economic evaluations of personalised medicine.
KeywordsCost Aspect Hospital Inpatient Care Important Cost Driver Patient Time Cost Colorectal Cancer Care
Role of the Funding Source
This research is supported by the German Federal Ministry of Education and Research (BMBF), project grant no. 01EX1013B, as part of the Centre of Excellence for Medical Technology.
- 7.Damm O, Hodek JM, Greiner W. Methodological standards for cost-of-illness studies using breast cancer, prostate cancer and colon cancer as an example. Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen. 2009;103(6):305–16. Methodische Standards von Krankheitskostenstudien am Beispiel von Brust-, Prostata- und Darmkrebs.Google Scholar
- 8.Segel J. Cost-of-illness studies—a primer. Research Triangle Park: RTI International; 2006. http://www.rti.org/pubs/coi_primer.pdf. Updated 24/03/2012.
- 14.Selke B, Durand I, Marissal JP, Chevalier D, Lebrun T. Cost of colorectal cancer in France in 1999. Gastroen Clin Biol. 2003;27(1):22–7.Google Scholar