Pharmacotherapy for Persistent Posttraumatic Headaches in Children and Adolescents: A Brief Review of the Literature
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Concussion, now most often referred to as mild traumatic brain injury in recent literature, is common in pediatrics, and headache is often the most common complaint post-injury. Although most children and adolescents recover within 1–2 weeks, some develop frequent and debilitating headaches that can last for months or longer. Most clinicians would agree on the importance of managing both acute and persistent posttraumatic headaches appropriately to speed recovery, minimize disability, maximize function, and improve quality of life, but there are no well-established guidelines to instruct physicians in doing so. As this continues to be a developing field, there is much we still need to learn about concussion and the appropriate strategies to prevent and treat these injuries and their sequelae. This review is intended to help providers understand the current evidence, and sometimes the lack thereof, and ultimately to lead to improved care for children with headaches after mild traumatic brain injury.
Compliance with Ethical Standards
No funding was received for the preparation of this review.
Conflict of Interest
Joanne Kacperski has no conflicts of interest to report.
- 12.Babcock L, Byczkowski T, Wade SL, Ho M, Mookerjee S, Bazarian JJ. Predicting postconcussion syndrome after mild traumatic brain injury in children and adolescents who present to the emergency department. Arch Pediatr Adolesc Med. 2012;167(2):156–61.Google Scholar
- 13.Blume HK. Headaches after concussion in pediatrics: a review. Curr Pain Headahce Rep. 2015;19(9):19–42.Google Scholar
- 19.Blume H, Temkin N,Wang J, Monica VS, Jaffe KM, Durbin D, Dorsch A, Rivara FP. Headache following mild TBI in children: what are the risks? Abstracts of the 2013 International Headache Congress, 27–30 June 2013, Boston, MA, USA. Cephalalgia. 2013;33 (8 Supp.):244.Google Scholar
- 33.Kacperski J, Kabbouche MA, O’Brien HL, Hershey AD. Headache in the pediatric patient. case-based diagnosis and management of headache disorders. Siva, Lampl eds, Switzerland. 2014.Google Scholar
- 36.Giza CC, Kutcher JS, Ashwal S, Barth J, Getchius TS, Gioia GA, Gronseth GS, Guskiewicz K, Mandel S, Manley G, McKeag DB, Thurman DJ, Zafonte R. Summary of evidence-based guideline update: evaluation and management of concussion in sports: Report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2013;80(24):2250–7.CrossRefPubMedPubMedCentralGoogle Scholar
- 39.Kuppermann N, Holmes JF, Dayan PS, Hoyle JD Jr, Atabaki SM, Holubkov R, Nadel FM, Monroe D, Stanley RM, Borgiali DA, Badawy MK, Schunk JE, Quayle KS, Mahajan P, Lichenstein R, Lillis KA, Tunik MG, Jacobs ES, Callahan JM, Gorelick MH, Glass TF, Lee LK, Bachman MC, Cooper A, Powell EC, Gerardi MJ, Melville KA, Muizelaar JP, Wisner DH, Zuspan SJ, Dean JM, Wootton-Gorges SL. Identification of children at very low risk of clinically important brain injuries after head trauma: a prospective cohort study”. Lancet. 2009;374(9696):1160–70.CrossRefPubMedGoogle Scholar
- 52.Dodick DW, Goadsby PJ, Silberstein SD, et al. Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, doubleblind, placebo-controlled, exploratory phase 2 trial. Lance Neurol. 2014;13:1100–7.CrossRefGoogle Scholar