Fibromyalgia: Treating Pain in the Juvenile Patient


Presently, evidence for the efficacy of medications for the treatment of juvenile fibromyalgia syndrome (JFMS) is limited. While there are medications approved by the US Food and Drug Administration (duloxetine, milnacipran and pregabalin) for adults with fibromyalgia syndrome, there are none for the treatment of JFMS. A variety of medications have been prescribed for the treatment of JFMS, including (but not limited to) non-opioid analgesics, opioids, anticonvulsants, antidepressants, and muscle relaxants. Psychological therapies, most prominently cognitive behavioral therapy, are the most evidenced-based treatment modalities for JFMS. A multidisciplinary approach, combining pharmacological, behavioral and exercise-based modalities is currently the standard of care for JFMS. In the future, more stringent randomized, controlled trials with longer follow-up periods are needed in order to determine the long-term efficacy and safety of medications in the treatment of JFMS. Additionally, improved recognition of JFMS will allow for better patient recruitment to permit for adequately powered study designs.

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Correspondence to David D. Sherry.

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SG and DDS declare they have no conflicts of interest to disclose.


Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number T32-AR007442 (Dr. Gmuca) and by the Snider Family (Dr. Sherry). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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This study does not qualify as human subjects research; therefore, ethical approval and informed consent were not required.

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Gmuca, S., Sherry, D.D. Fibromyalgia: Treating Pain in the Juvenile Patient. Pediatr Drugs 19, 325–338 (2017).

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