Pediatric Drugs

, Volume 19, Issue 3, pp 173–181 | Cite as

Hepatitis B During Pregnancy in Endemic Areas: Screening, Treatment, and Prevention of Mother-to-Child Transmission

  • Naichaya Chamroonkul
  • Teerha PiratvisuthEmail author
Therapy in Practice


The proper management of pregnant women infected with hepatitis B virus (HBV) is necessary to prevent maternal and fetal morbidity and mortality and to protect the baby from HBV infection. In the majority of cases, vertical transmission can be prevented with a universal screening program, HBV vaccine immunoprophylaxis, and administration of hepatitis B immunoglobulin (HBIg) for babies born to mothers with HBV. However, in mothers with a high viral load (>200,000 or >1,000,000 IU/ml, depending on the guideline), the chance of immunoprophylaxis failure remains high. The standard recommendation is to give an antiviral agent during the third trimester in these patients. US FDA pregnancy category B agents such as tenofovir and telbivudine are allowed through all trimesters of pregnancy. Breastfeeding for patients who receive antiviral agents can be allowed after a risk–benefit discussion with the patient.


Lamivudine Tenofovir Telbivudine MTCT Prophylaxis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Compliance with Ethical Standards

Conflict of interest

Naichaya Chamroonkul has no conflicts of interest. Teerha Piratvisuth has received research grants from Geliad, MSD, and BMS and consulting fees or speakers’ honoraria from Geliad, MSD, BMS, Roche, GSK, Novatis, and Bayers.


No sources of funding were used to support the writing of this manuscript.


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Division of Gastroenterology and Hepatology, Department of Medicine, Faculty of MedicinePrince of Songkla UniversitySongkhlaThailand
  2. 2.Department of Medicine, NKC Institute of Gastroenterology and HepatologyPrince of Songkla UniversityHat YaiThailand

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