Valutazione economica del sistema di aferesi per la rimozione di granulociti e macrofagi (Adacolumn®) rispetto a biologico nel trattamento della colite ulcerosa moderata-severa in pazienti steroido-dipendenti o resistenti in Italia

  • R. Ravasio
  • G. De Silvestro
  • A. Saggioro
  • G. C. Sturniolo
  • P. Vernia
Articolo Originale



The treatment of chronic inflammatory bowel disease (IBD) is always a challenge for gastroenterologists dealing with this type of condition. The development of granulocyte-monocyte apheresis (GMA) appears to be an innovative approach, comprising both treatment safety and therapeutic potential.


To assess the cost-consequence of granulocyte monocyte adsorption—apheresis (GMA-Apheresis; Adacolumn®) versus infliximab in the treatment of moderate-to-severe ulcerative colitis (UC) in steroid-dependent or steroid-resistant patients.


One-year cost-consequence analysis from the Italian National Health Service (NHS) perspective using a decision tree model was carried out. Probabilities of each event were derived from literature and an expert panel. Direct medical costs were obtained from official sources (€2013).


The average annual cost per patient who started the treatment with GMA-Apheresis was estimated to be €13,931.33; the cost was estimated to be €15,179.08, starting the treatment with infliximab. The sensitivity analysis confirmed the results of the base case.


We performed a cost-consequence analysis focused on the use of GMA-Apheresis (Adacolumn®) in the therapeutic management of moderate-to-severe UC in steroid-dependent or steroid-resistant patients. From the Italian NHS perspective, GMA-Apheresis is a cost-saving strategy compared with infliximab.

Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • R. Ravasio
    • 1
  • G. De Silvestro
    • 2
  • A. Saggioro
    • 3
  • G. C. Sturniolo
    • 4
  • P. Vernia
    • 5
  1. 1.Springer Healthcare Italia SrlMilanoItalia
  2. 2.Servizio trasfusionaleAzienda Ospedale Università di PadovaPadovaItalia
  3. 3.UOC di GastroenterologiaOspedale dell’AngeloVenezia-MestreItalia
  4. 4.Dipartimento di Scienze Chirurgiche e GastroenterologicheUniversità degli Studi di PadovaPadovaItalia
  5. 5.Università di Roma La SapienzaRomaItalia

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