Be aware that the benefits of biological drugs in multiple sclerosis may be offset by their capacity to cause immunological complications

  • Adis Medical WritersEmail author
Drug Reactions and Interactions


Biological immunotherapies for multiple sclerosis (MS) include recombinant proteins (preparations of interferon-β) and monoclonal antibodies (e.g. natalizumab, alemtuzumab, ocrelizumab and off-label rituximab). They have shown unprecedented efficacy in the treatment of MS; however, they are all immunogenic and have been associated with immunological complications, such as neutralizing immunogenicity, secondary immunodeficiency and secondary autoimmunity.


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Conflict of interest

The article was adapted from Drug Safety 2019; 42(8):941–56 by employees of Adis International Ltd./Springer Nature, who are responsible for the article content and declare no conflicts of interest.


The preparation of this review was not supported by any external funding.


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Authors and Affiliations

  1. 1.Springer NatureAucklandNew Zealand

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