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Drugs & Therapy Perspectives

, Volume 35, Issue 12, pp 618–618 | Cite as

First reports of adverse drug reactions

Drug Reactions and Interactions
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Table 1 contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks by Reactions Weekly, the Adis drug safety newsletter. Reactions Weekly provides summaries of adverse drug reaction news sourced from journals, scientific meetings, media releases, regulatory agency websites, and bulletins from the National Centers that participate in the WHO International Drug Monitoring Programme.
Table 1

First published reports of adverse drug reactions recently identified by Reactions Weekly

Drug and adverse reaction

References

CB-1158: immune thrombocytopenia (serious)

Sadek M, El Hachem G, Vercruyssen M. Drug-induced thrombocytopenia [abstract no. MDS076]. Clin Lymphoma Myeloma Leuk. 2019;19 (Suppl 1):S338.  https://doi.org/10.1016/j.clml.2019.07.336

Daratumumab: choroidal effusion (serious)

Rasmussen PK, Kiilgaard JF, Salomo M. Association of choroidal effusion and infusion of daratumumab. JAMA Ophthalmol. 2019;137(7):853-4.  https://doi.org/10.1001/jamaophthalmol.2019.1427

GAD65-vaccine (Diamyd®; antigen-specific immunotherapy for the treatment of autoimmune diabetes): autoimmune encephalitis (serious)

Allen S, Kabir MA, Subramaniam T, et al. A young woman with palatal myoclonus, memory loss and seizures [abstract no. P2.2-050]. Neurology. 2019;92 (15 Suppl). https://n.neurology.org/content/92/15_Supplement

Origanum (oregano oil): chemical injury to the larynx (serious)

Soldatova L, Bassett RA, Leahy K. Toxic potential of oregano oil ingestion [abstract ]. Otolaryngol Head Neck Surg. 2019;161 (Suppl 2): P229.  https://doi.org/10.1177/0194599819858142e

Osimertinib: jaw osteonecrosis and easy finger cuts (serious)

Subramanian G, Kashikar S, Fitzhugh V, et al. Osimertinib and jaw osteonecrosis? A case report. Int J Cancer. 2019;145(7):2003–5.  https://doi.org/10.1002/ijc.32399

Ramucirumab: skin ulcer and delayed wound healing (serious)

Taira K, Nadatani Y, Hirano S, et al. Large skin ulcer and delayed wound healing around a colostomy in a patient with metastatic colorectal cancer receiving vascular endothelial growth factor receptor-2 inhibitor therapy. Case Rep Oncol. 2019;12(2):370–5.  https://doi.org/10.1159/000500412

Ribociclib: Glanzmann thrombasthenia

Awidi AS, Bawa’neh HS, Al-Showbaki LN, et al. Ribociclib causing transient Glanzmann thrombasthenia-like picture: a report of 4 cases. Clin Breast Cancer. 2019;19(5):e593–5.  https://doi.org/10.1016/j.clbc.2019.06.002

An event is serious (US FDA MedWatch definition) when the patient outcome is death, life threatening, hospitalization, disability, congenital anomaly or requires intervention to prevent permanent impairment or damage

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© Springer Nature Switzerland AG 2019

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