First reports of adverse drug reactions

Drug Reactions and Interactions
Table 1 contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks by Reactions Weekly, the Adis drug safety newsletter. Reactions Weekly provides summaries of adverse drug reaction news sourced from journals, scientific meetings, media releases, regulatory agency websites, and bulletins from the National Centers that participate in the WHO International Drug Monitoring Programme.
Table 1

First published reports of adverse drug reactions recently identified by Reactions Weekly

Drug and adverse reaction


Cobimetinib + vemurafenib: granulomatous dermatitis and erythema induration (serious)

Iafolla MA, Ramsay J, Wismer J, et al. Cobimetinib- and vemurafenib-induced granulomatous dermatitis and erythema induratum: a case report. SAGE Open Med Case Rep. Epub 2019.

Durvalumab: bilateral anterior optic neuropathy, vestibular neuritis and cerebellar syndrome (serious)

Olivier P, Larrieu-Ciron D, Fabre A, et al. Unexpected serious ocular and neurological immune-related adverse events in a patient treated with the anti-PD-L1 durvalumab [abstract no. PS1-064]. Fundam Clin Pharmacol 2019;33(Suppl 1):63.

Fluocinonide: central serous retinopathy (serious)

O’Brien P, Young RC, Ghafoori SD, et al. Central serous retinopathy associated with topical oral corticosteroid use: a case report. J Med Case Rep. 2019;13:article 201.

Metronidazole: secondary haemophagocytic lymphohistiocytosis (serious)

Iio K, Ariyama Y, Tomita H, et al. Secondary haemophagocytic lymphohistiocytosis associated with metronidazole. Postgrad Med J. 2019;95(1125):390.

Nabilone: mental confusion

Pellesi L, Verga MC, De Maria N, et al. Nabilone administration in refractory chronic diarrhea: a case series. BMC Gastroenterol, 2019;19(1):105.

Nalmefene: psychotic decompensation (serious)

Salles J, Ponté C, Schmitt L. Psychotic decompensation during nalmefene treatment in a patient with schizoaffective disorder: a case report. J Dual Diagn. 2019;15(2):118–21.

Ramipril: expectoration of bronchial casts

Plümacher SK, Paul T, Sigler M. Expectoration of bronchial casts caused by ramipril treatment [abstract]. Thorac Cardiovasc Surg Rep. 2019;67(Suppl 2):S101–28.

Sodium polystyrene sulfonate: chronic pouchitis

Lander J, Richardson E, Kaufman A. Another RESIN for pouchitis: chronic pouchitis with erosion secondary to sodium polystyrene sulfonate crystals. Am J Gastroenterol. 2018;113(3):327.

An event is serious (US FDA MedWatch definition) when the patient outcome is death, life threatening, hospitalization, disability, congenital anomaly or requires intervention to prevent permanent impairment or damage

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© Springer Nature Switzerland AG 2019

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