First reports of adverse drug reactions

Drug Reactions and Interactions
Table 1 contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks by Reactions Weekly, the Adis drug safety newsletter. Reactions Weekly provides summaries of adverse drug reaction news sourced from journals, scientific meetings, media releases, regulatory agency websites, and bulletins from the National Centers that participate in the WHO International Drug Monitoring Programme.
Table 1

First published reports of adverse drug reactions recently identified by Reactions Weekly

Drug and adverse reaction


Antithymocyte-globulin: reversible cerebral vasoconstriction syndrome (serious)

Yamamoto A, Meguri Y, Fukuda A, et al. A case of reversible cerebral vasoconstriction syndrome developing during treatment of adult aplastic anemia. Ann Hematol. 2019;98(2):511–3.

Aripiprazole abuse/overdose: second degree atrioventricular following a suicide attempt (serious)

Russo L, Rizzo A, Di Vincenzo A, et al. Aripiprazole overdose and transient 2:1 second degree atrioventricular block: only a coincidence? Curr Drug Saf. 2019.

Epinephrine/mepivacaine: retinal toxicity following accidental intravitreal administration (serious)

López-Herrero F, Sánchez-Vicente JL, Monge-Esquivel J, et al. Retinal toxicity after accidental intravitreal injection of mepivacaine and adrenaline [in Spanish]. Arch Soc Esp Oftalmol. 2018;93(3):143–6.

Eribulin: tumour lysis syndrome (serious)

Pabon C, Esnakula AK, Daily K. Tumour lysis syndrome following eribulin for metastatic uterine leiomyosarcoma. BMJ Case Rep. 2018;11(1).

Exenatide: drug-induced immune thrombocytopenia (serious)

Vallatharasu Y, Hayashi-Tanner Y, Polewski PJ, et al. Severe, prolonged thrombocytopenia in a patient sensitive to exenatide. Am J Hematol. 2019;94(3):E78–E80.|

Fulvestrant: fixed drug eruption (serious)

Broche C, Pralong P, Gil H, et al. Fixed drug eruption caused by fulvestrant confirmed by skin tests: first case. Contact Dermatitis. 2019;80(3):184–6.

Methylprednisone: Orf diseasea

Kostopoulos M, Gerodimos CA, Batsila E, et al. Orf disease in a patient with rheumatoid arthritis. Mediterr J Rheum. 2018;29(2):89–91.

Pembrolizumab: prurigo nodularis (serious)

Fattore D, Panariello L, Annunziata MC, et al. Prurigo nodularis and pembrolizumab: a therapeutic challenge. Eur J Cancer. 2019;110:8–10.

Valsartan: malignant melanoma (serious)

Tchernev G, Temelkova I. Valsartan induced melanoma?! First description in medical literature! Open Access Maced J Med Sci. 2018;6(12):2378–80.

An event is serious (US FDA MedWatch definition) when the patient outcome is death, life threatening, hospitalization, disability, congenital anomaly or requires intervention to prevent permanent impairment or damage

aRare viral infection, which affects patients involved in the care of livestock. Also known as ecthyma contagious, contagious pustular dermatitis and infectious euphoria

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© Springer Nature Switzerland AG 2019

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