A critical review of pyritinol

  • Alok SinghEmail author
  • Vinay Purohit
Review Article


Pyritinol (pyrithioxine) is a combination of two molecules of vitamin B6 (pyridoxine) with disulfide linkage. Its pharmacokinetic profile mimics that of its parent compound. Because it crosses the blood–brain barrier, its major clinical utility is in brain-related disorders. Pyritinol regulates signalling pathways of various neurotransmitters including acetylcholine, γ-aminobutyric acid, N-methyl-d-aspartate, etc. Pyritinol has also been shown to act as an antioxidant and anti-inflammatory agent, and also reduces plasma viscosity. It is indicated in paediatric populations to treat learning disabilities, developmental dysphasia, postnatal hypoxia and other cognitive disorders. In adults, it is indicated for improving cognition and memory, Alzheimer’s disease, multi-infarct dementia and rheumatoid arthritis. It has also been investigated in many other clinical conditions, but results are inconclusive. The positive results of many animal studies have not been replicated into consistent clinical success. This review aims to discuss potential uses of pyritinol and its future prospects.


Compliance with ethical standards

Conflict of interest

Authors declare no conflicts of interest relevant to this article.


No funding received from any source.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of PharmacologyAll India Institute of Medical SciencesRaipurIndia
  2. 2.Procter and GambleMumbaiIndia

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