Ginkgo biloba extract EGb 761® in the symptomatic treatment of mild-to-moderate dementia: a profile of its use
- 17 Downloads
EGb 761® (Tanakan®) is a standardized extract of Ginkgo biloba leaves that has demonstrated protective properties against neuronal and vascular damage. Overall, in randomized, placebo-controlled clinical trials and meta-analyses in adults with mild-to-moderate dementia, EGb 761® displayed positive effects, with changes from baseline in outcomes related to cognition, behaviour and global change that are generally better than those shown with placebo. EGb 761® is generally well tolerated, with no safety issues being identified during its many years of widespread use.
The manuscript was reviewed by: M. Mazza, Department of Neurosciences, Institute of Psychiatry, Catholic University of Sacred Heart, Rome, Italy; M.C. Woodward, Aged and Residential Care Services, Austin Health, University of Melbourne, Heidelberg, VIC, Australia; W.S. Zirker, Division of Geriatric Medicine, Crozer-Chester Medical Center, Upland, PA, USA. During the peer review process, Ipsen Pharma, the marketing-authorization holder of EGb 761®, was also offered an opportunity to provide a scientific accuracy review of their data. Changes resulting from comments received were made on the basis of scientific and editorial merit.
Compliance with ethical standards
The preparation of this review was not supported by any external funding.
Conflict of interest
K. McKeage and K.A. Lyseng-Williamson are employees of Adis/Springer, are responsible for the article content and declare no conflicts of interest.
- 8.Tanakan [standardized ginkgo biloba extract (EGb 761)] 40 mg film-coated tablets and 40 mg/ml oral solution: summary of product characteristics (Czech Republic). Boulogne-Billancourt: Ipsen Pharma; 2016.Google Scholar
- 9.Tanakan [standardized ginkgo biloba extract (EGb 761)] 40 mg film-coated tablets and 40 mg/ml oral solution: summary of product characteristics (Lithuania). Boulogne-Billancourt: Ipsen Pharma; 2015.Google Scholar
- 13.Beck SM, Ruge H, Schindler C, et al. Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment: a randomized double-blind placebo-controlled trial. Hum Psychopharmacol. 2016;31(3):227–42.CrossRefPubMedPubMedCentralGoogle Scholar
- 14.Bastianetto S, Quirion R. EGb 761 is a neuroprotective agent against beta-amyloid toxicity. Cell Mol Biol (Noisy-le-Grand). 2002;48(6):693–7.Google Scholar
- 43.Chen LE, Wu F, Zhao A, et al. Protection efficacy of the extract of Ginkgo biloba against the learning and memory damage of rats under repeated high sustained +Gz exposure. Evid Based Complement Altern Med. 2016;2016:6320586.Google Scholar
- 58.Nikolova G, Yancheva S, Raychev I, et al. Ginkgo biloba extract in dementia: a 22-week randomised, placebo-controlled, double-blind trial [in Bulgarian]. Bulg Neurol. 2013;14(3):139–43.Google Scholar
- 71.European Union herbal monograph on Ginkgo biloba L., folium. London; European Medicines Agency; 2015.Google Scholar