Consider potential drug interactions when starting combination therapy with antiepileptic drugs
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Alternative monotherapy and adjunctive therapy are both valid options following failure of initial monotherapy with an antiepileptic drug (AED). Depending on the cause of initial failure of AED monotherapy, one option may be favoured over the other. When proceeding with adjunctive therapy, considerations should include choosing an agent with a different mechanism of action to that of the existing antiepileptic drug and avoiding unfavourable pharmacokinetic interactions (e.g. those related to hepatic metabolism and enzyme induction).
The preparation of this review was not supported by any external funding.
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Conflict of interest
The article was adapted from CNS Drugs 2017; 31(10):835–44  by employees of Adis/Springer, who are responsible for the article content and declare no conflicts of interest.