Consider using opioids to treat restless legs syndrome in patients who have become refractory or intolerant to other treatments
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Although initially effective in treating restless legs syndrome (RLS), some treatments, such as dopamine agonists, eventually lose efficacy and may worsen RLS symptoms. According to current evidence, opioids are effective, and may be an appropriate option for treating patients with refractory RLS or those who cannot tolerant other treatments, given that the potential risk factors involved are carefully considered.
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Conflict of interest
The article was adapted from Drugs 2017;77(12):1337-44  by employees of Adis/Springer, who are responsible for the article content and declare no conflicts of interest.
The preparation of this review was not supported by any external funding.
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