Drugs & Aging

, Volume 36, Issue 1, pp 95–101 | Cite as

Authors’ Reply to Kahlaee et al: “A Systematic Review and Meta-Analyses of the Association Between Anti-hypertensive Classes and the Risk of Falls Among Older Adults”

  • Ka Keat Lim
  • Hui Ting Ang
  • Yu Heng Kwan
  • Chuen Seng Tan
  • Truls Ostbye
  • Lian Leng LowEmail author
Letter to the Editor

We recently performed a systematic review and meta-analyses to examine the associations between antihypertensive classes and three types of fall outcomes: falls, injurious falls and recurrent falls [1]. Past systematic reviews have not shown a consistent association between antihypertensive classes and fall outcomes, and we wanted to take advantage of recent studies with large samples to address this issue. Kahlaee et al. [2] studied a similar topic and sought two clarifications from us: whether we pooled hazard ratios (HRs) and odds ratios (ORs) and whether we considered time–risk analyses (i.e. the association between initiation of antihypertensive medications at various time intervals and falls), similar to the analyses they performed. We would like to respond to their letter here.

Pooling of Effect Size Estimates

We agree that HRs and ORs have somewhat different interpretations. We only pooled estimates with ORs, as stated in the methodology section of our manuscript, and excluded...


Compliance with Ethical Standards

Conflict of interest

KK Lim, HT Ang, YH Kwan, CS Tan, T Ostbye and LL Low have no conflicts of interest that might be relevant to the contents of this letter.


No sources of funding were used to prepare this letter.


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Ka Keat Lim
    • 1
  • Hui Ting Ang
    • 2
  • Yu Heng Kwan
    • 1
  • Chuen Seng Tan
    • 3
  • Truls Ostbye
    • 1
  • Lian Leng Low
    • 4
    • 5
    Email author
  1. 1.Program in Health Services and Systems Research, Duke-NUS Medical SchoolSingaporeRepublic of Singapore
  2. 2.Department of Pharmacy, Faculty of ScienceNational University of SingaporeSingaporeRepublic of Singapore
  3. 3.Saw Swee Hock School of Public HealthNational University of Singapore and National University Health SystemSingaporeRepublic of Singapore
  4. 4.Duke-NUS Medical SchoolSingaporeRepublic of Singapore
  5. 5.Department of Family Medicine and Continuing CareSingapore General HospitalSingaporeRepublic of Singapore

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