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Drugs

, Volume 78, Issue 13, pp 1289–1296 | Cite as

Fenofibrate and Dyslipidemia: Still a Place in Therapy?

  • Nicola Tarantino
  • Francesco Santoro
  • Michele Correale
  • Luisa De Gennaro
  • Silvio Romano
  • Matteo Di Biase
  • Natale Daniele Brunetti
Current Opinion

Abstract

Dyslipidemia is one of the major cardiovascular risk factors, but beyond statin treatment—which represents the cornerstone of therapy—a relevant practical uncertainty regards the use of fibrate derivatives. In the lack of successful results from the main cardiovascular trials, guidelines recommend the use of peroxisome proliferator-activated receptor agonists in selected cases, i.e. patients with true atherogenic dyslipidemia. However, recent observations indicate that fenofibrate treatment may provide a reliable complementary support against residual cardiovascular risk. We therefore summarize current evidence on fenofibrate, seeking to provide an updated interpretation of recent studies in the field.

Notes

Compliance with Ethical Standards

Funding

No external funding was used in the preparation of this manuscript.

Conflict of interest

Nicola Tarantino, Francesco Santoro, Michele Correale, Luisa De Gennaro, Silvia Romano, Matteo Di Biase and Natale Daniele Brunetti declare that they have no conflicts of interest that might be relevant to the contents of this manuscript.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Nicola Tarantino
    • 1
  • Francesco Santoro
    • 1
    • 2
  • Michele Correale
    • 3
  • Luisa De Gennaro
    • 4
  • Silvio Romano
    • 5
  • Matteo Di Biase
    • 6
  • Natale Daniele Brunetti
    • 1
  1. 1.Department of Medical and Surgical SciencesUniversity of FoggiaFoggiaItaly
  2. 2.Asklepios Klinik Sankt GeorgHamburgGermany
  3. 3.Cardiology DepartmentOspedali Riuniti University HospitalFoggiaItaly
  4. 4.Ospedale San PaoloBariItaly
  5. 5.University of L’AquilaL’AquilaItaly
  6. 6.Clinica Santa MariaGruppo Villa Maria Care and ResearchBariItaly

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