Drugs

, Volume 75, Issue 4, pp 339–351 | Cite as

Preventive Analgesia and Novel Strategies for the Prevention of Chronic Post-Surgical Pain

  • Hance Clarke
  • Michael Poon
  • Aliza Weinrib
  • Rita Katznelson
  • Kirsten Wentlandt
  • Joel Katz
Leading Article

Abstract

Chronic post-surgical pain (CPSP) is a serious complication of major surgery that can impair a patient’s quality of life. The development of CPSP is a complex process which involves biologic, psychosocial, and environmental mechanisms that have yet to be fully understood. Currently perioperative pharmacologic interventions aim to suppress and prevent sensitization with the aim of reducing pain and analgesic requirement in acute as well as long-term pain . Despite the detrimental effects of CPSP on patients, the body of literature focused on treatment strategies to reduce CPSP remains limited and continues to be understudied. This article reviews the main pharmacologic candidates for the treatment of CPSP, discusses the future of preventive analgesia, and considers novel strategies to help treat acute post-operative pain and lessen the risk that it becomes chronic. In addition, this article highlights important areas of focus for clinical practice including: multimodal management of CPSP patients, psychological modifiers of the pain experience, and the development of a Transitional Pain Service specifically designed to manage patients at high risk of developing chronic post-surgical pain.

Notes

Acknowledgments

HC is supported by a Merit Award (Department of Anaesthesia, University of Toronto) and the STAGE Training Program in Genetic Epidemiology (Canadian Institutes of Health Research, CIHR) and a grant by the Physicians Services Incorporated Foundation. JK is supported by a Canada Research Chair in Health Psychology. The authors of this manuscript have no conflicts of interest to declare.

References

  1. 1.
    Searle R, Simpson K. Chronic post-surgical pain. Contin Educ Anaesth Crit Care Pain. 2010;10(1):12–4.CrossRefGoogle Scholar
  2. 2.
    Clarke H, Soneji N, Ko DT, Yun L, Wijeysundera DN. Rates and risk factors for prolonged opioid use after major surgery: population based cohort study. BMJ. 2014;11(348):g1251.CrossRefGoogle Scholar
  3. 3.
    Perkins FM, Kehlet H. Chronic pain as an outcome of surgery. A review of predictive factors. Anesthesiology. 2000;93(4):1123–33.CrossRefPubMedGoogle Scholar
  4. 4.
    Macrae WA. Chronic post-surgical pain: 10 years on. Br J Anaesth. 2008;101(1):77–86.CrossRefPubMedGoogle Scholar
  5. 5.
    Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367(9522):1618–25.CrossRefPubMedGoogle Scholar
  6. 6.
    Steegers MA, Snik DM, Verhagen AF, van der Drift MA, Wilder-Smith OH. Only half of the chronic pain after thoracic surgery shows a neuropathic component. J Pain. 2008;9(10):955–61.CrossRefPubMedGoogle Scholar
  7. 7.
    Ivens D, Hoe AL, Podd TJ, Hamilton CR, Taylor I, Royle GT. Assessment of morbidity from complete axillary dissection. Br J Cancer. 1992;66(1):136–8.CrossRefPubMedCentralPubMedGoogle Scholar
  8. 8.
    Katz J, Seltzer Z. Transition from acute to chronic postsurgical pain: risk factors and protective factors. Expert Rev Neurother. 2009;9(5):723–44.CrossRefPubMedGoogle Scholar
  9. 9.
    Pogatzki-Zahn EM, Zahn PK. From preemptive to preventive analgesia. Curr Opin Anaesthesiol. 2006;19(5):551–5.CrossRefPubMedGoogle Scholar
  10. 10.
    Katz J, Clarke H, Seltzer Z. Review article: preventive analgesia: quo vadimus? Anesth Analg. 2011;113(5):1242–53.CrossRefPubMedGoogle Scholar
  11. 11.
    Chaparro LE, Smith SA, Moore RA, Wiffen PJ, Gilron I. Pharmacotherapy for the prevention of chronic pain after surgery in adults. Cochrane Database Syst Rev. 2013;7:CD008307.PubMedGoogle Scholar
  12. 12.
    Albi-Feldzer A, Mouret-Fourme EE, Hamouda S, Motamed C, Dubois PY, Jouanneau L, et al. A double-blind randomized trial of wound and intercostal space infiltration with ropivacaine during breast cancer surgery: effects on chronic postoperative pain. Anesthesiology. 2013;118(2):318–26.CrossRefPubMedGoogle Scholar
  13. 13.
    Merivirta R, Aarimaa V, Aantaa R, Koivisto M, Leino K, Liukas A, et al. Postoperative fentanyl patch versus subacromial bupivacaine infusion in arthroscopic shoulder surgery. Arthroscopy. 2013;29(7):1129–34.CrossRefPubMedGoogle Scholar
  14. 14.
    Onan B, Onan IS, Kilickan L, Sanisoglu I. Effects of epidural anesthesia on acute and chronic pain after coronary artery bypass grafting. J Card Surg. 2013;28(3):248–53.CrossRefPubMedGoogle Scholar
  15. 15.
    Williams D, Petruccelli D, Paul J, Piccirillo L, Winemaker M, de Beer J. Continuous infusion of bupivacaine following total knee arthroplasty: a randomized control trial pilot study. J Arthroplasty. 2013;28(3):479–84.CrossRefPubMedGoogle Scholar
  16. 16.
    Corsini T, Cuvillon P, Forgeot A, Chapelle C, Seffert P, Chauleur C. Single-dose intraincisional levobupivacaine infiltration in caesarean postoperative analgesia: a placebo-controlled double-blind randomized trial. Ann Fr Anesth Reanim. 2013;32(1):25–30.CrossRefPubMedGoogle Scholar
  17. 17.
    Cohen SP, Galvagno SM, Plunkett A, Harris D, Kurihara C, Turabi A, et al. A multicenter, randomized, controlled study evaluating preventive etanercept on postoperative pain after inguinal hernia repair. Anesth Analg. 2013;116(2):455–62.CrossRefPubMedGoogle Scholar
  18. 18.
    Joshi SS, Jagadeesh AM. Efficacy of perioperative pregabalin in acute and chronic post-operative pain after off-pump coronary artery bypass surgery: a randomized, double-blind placebo controlled trial. Ann Card Anaesth. 2013;16(3):180–5.CrossRefPubMedGoogle Scholar
  19. 19.
    Martinez V, Szekely B, Lemarie J, Martin F, Gentili M, Ben Ammar S, et al. The efficacy of a glial inhibitor, minocycline, for preventing persistent pain after lumbar discectomy: a randomized, double-blind, controlled study. Pain. 2013;154(8):1197–203.CrossRefPubMedGoogle Scholar
  20. 20.
    Ogurlu M, Sari S, Kucuk M, Bakis M, Ugur B, Eshraghi YE, et al. Comparison of the effect of propofol and sevoflurane anaesthesia on acute and chronic postoperative pain after hysterectomy. Anaesth Intensive Care. 2014;42(3):365–70.PubMedGoogle Scholar
  21. 21.
    Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, et al. Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. J Pharmacol Exp Ther. 2002;303(3):1199–205.CrossRefPubMedGoogle Scholar
  22. 22.
    Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J. The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis. Anesth Analg. 2012;115(2):428–42.CrossRefPubMedGoogle Scholar
  23. 23.
    Clarke H, Pereira S, Kennedy D, Andrion J, Mitsakakis N, Gollish J, et al. Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty. Acta Anaesthesiol Scand. 2009;53(8):1073–83.CrossRefPubMedGoogle Scholar
  24. 24.
    Nikolajsen L, Finnerup NB, Kramp S, Vimtrup AS, Keller J, Jensen TS. A randomized study of the effects of gabapentin on postamputation pain. Anesthesiology. 2006;105(5):1008–15.CrossRefPubMedGoogle Scholar
  25. 25.
    Sen H, Sizlan A, Yanarates O, Emirkadi H, Ozkan S, Dagli G, et al. A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy. Anesth Analg. 2009;109(5):1645–50.CrossRefPubMedGoogle Scholar
  26. 26.
    Sen H, Sizlan A, Yanarates O, Senol MG, Inangil G, Sucullu I, et al. The effects of gabapentin on acute and chronic pain after inguinal herniorrhaphy. Eur J Anaesthesiol. 2009;26(9):772–6.CrossRefPubMedGoogle Scholar
  27. 27.
    Amr YM, Yousef AA. Evaluation of efficacy of the perioperative administration of Venlafaxine or gabapentin on acute and chronic postmastectomy pain. Clin J Pain. 2010;26(5):381–5.CrossRefPubMedGoogle Scholar
  28. 28.
    Brogly N, Wattier JM, Andrieu G, Peres D, Robin E, Kipnis E, et al. Gabapentin attenuates late but not early postoperative pain after thyroidectomy with superficial cervical plexus block. Anesth Analg. 2008;107(5):1720–5.CrossRefPubMedGoogle Scholar
  29. 29.
    Cheng JK, Chiou LC. Mechanisms of the antinociceptive action of gabapentin. J Pharmacol Sci. 2006;100(5):471–86.CrossRefPubMedGoogle Scholar
  30. 30.
    Clarke HA, Katz J, McCartney CJ, Stratford P, Kennedy D, Page MG, et al. Perioperative gabapentin reduces 24 h opioid consumption and improves in-hospital rehabilitation but not post-discharge outcomes after total knee arthroplasty with peripheral nerve block. Br J Anaesth. 2014;113(5):855–64.CrossRefPubMedGoogle Scholar
  31. 31.
    Gianesello L, Pavoni V, Barboni E, Galeotti I, Nella A. Perioperative pregabalin for postoperative pain control and quality of life after major spinal surgery. J Neurosurg Anesthesiol. 2012;24(2):121–6.CrossRefPubMedGoogle Scholar
  32. 32.
    Pesonen A, Suojaranta-Ylinen R, Hammaren E, Kontinen VK, Raivio P, Tarkkila P, et al. Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. Br J Anaesth. 2011;106(6):873–81.CrossRefPubMedGoogle Scholar
  33. 33.
    Buvanendran A, Kroin JS, Della Valle CJ, Kari M, Moric M, Tuman KJ. Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial. Anesth Analg. 2010;110(1):199–207.CrossRefPubMedGoogle Scholar
  34. 34.
    Clarke H, Wijeysundera D, Bonin R, Orser B, Englesakis M, Katz J. Pregabalin effective for the prevention of chronic postsurgical pain: really? In reply. Anesth Analg. 2013;116(2):508–9.CrossRefPubMedGoogle Scholar
  35. 35.
    Singla NK, Chelly JE, Lionberger DR, Gimbel J, Sanin L, Sporn J, et al. Pregabalin for the treatment of postoperative pain: results from three controlled trials using different surgical models. J Pain Res. 2014;23(8):9–20.CrossRefGoogle Scholar
  36. 36.
    Samad TA, Sapirstein A, Woolf CJ. Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol Med. 2002;8(8):390–6.CrossRefPubMedGoogle Scholar
  37. 37.
    Clarke H, Woodhouse LJ, Kennedy D, Stratford P, Katz J. Strategies aimed at preventing chronic post-surgical pain: comprehensive perioperative pain management after total joint replacement surgery. Physiother Can. 2011;63(3):289–304 (Summer).CrossRefPubMedCentralPubMedGoogle Scholar
  38. 38.
    Koppert W, Wehrfritz A, Korber N, Sittl R, Albrecht S, Schuttler J, et al. The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans. Pain. 2004;108(1–2):148–53.CrossRefPubMedGoogle Scholar
  39. 39.
    Sycha T, Anzenhofer S, Lehr S, Schmetterer L, Chizh B, Eichler HG, et al. Rofecoxib attenuates both primary and secondary inflammatory hyperalgesia: a randomized, double blinded, placebo controlled crossover trial in the UV-B pain model. Pain. 2005;113(3):316–22.CrossRefPubMedGoogle Scholar
  40. 40.
    Buvanendran A, Kroin JS, Tuman KJ, Lubenow TR, Elmofty D, Moric M, et al. Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial. JAMA. 2003;290(18):2411–8.CrossRefPubMedGoogle Scholar
  41. 41.
    Meunier A, Aspenberg P, Good L. Celecoxib does not appear to affect prosthesis fixation in total knee replacement: a randomized study using radiostereometry in 50 patients. Acta Orthop. 2009;80(1):46–50.CrossRefPubMedCentralPubMedGoogle Scholar
  42. 42.
    Fransen M, Anderson C, Douglas J, MacMahon S, Neal B, Norton R, et al. Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial. BMJ. 2006;333(7567):519.CrossRefPubMedCentralPubMedGoogle Scholar
  43. 43.
    Lakdja F, Dixmerias F, Bussieres E, Fonrouge JM, Lobera A. Preventive analgesic effect of intraoperative administration of ibuprofen-arginine on postmastectomy pain syndrome. Bull Cancer. 1997;84(3):259–63.PubMedGoogle Scholar
  44. 44.
    Romundstad L, Breivik H, Roald H, Skolleborg K, Romundstad PR, Stubhaug A. Chronic pain and sensory changes after augmentation mammoplasty: long term effects of preincisional administration of methylprednisolone. Pain. 2006;124(1–2):92–9.CrossRefPubMedGoogle Scholar
  45. 45.
    Woolf CJ, Chong MS. Preemptive analgesia–treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg. 1993;77(2):362–79.CrossRefPubMedGoogle Scholar
  46. 46.
    Kissin I, Bright CA, Bradley EL Jr. The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations? Anesth Analg. 2000;91(6):1483–8.CrossRefPubMedGoogle Scholar
  47. 47.
    Perrin SB, Purcell AN. Intraoperative ketamine may influence persistent pain following knee arthroplasty under combined general and spinal anaesthesia: a pilot study. Anaesth Intensive Care. 2009;37(2):248–53.PubMedGoogle Scholar
  48. 48.
    Duale C, Sibaud F, Guastella V, Vallet L, Gimbert YA, Taheri H, et al. Perioperative ketamine does not prevent chronic pain after thoracotomy. Eur J Pain. 2009;13(5):497–505.CrossRefPubMedGoogle Scholar
  49. 49.
    Crousier M, Cognet V, Khaled M, Gueugniaud PY, Piriou V. Effect of ketamine on prevention of postmastectomy chronic pain. A pilot study. Ann Fr Anesth Reanim. 2008;27(12):987–93.CrossRefPubMedGoogle Scholar
  50. 50.
    Suzuki M, Haraguti S, Sugimoto K, Kikutani T, Shimada Y, Sakamoto A. Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy. Anesthesiology. 2006;105(1):111–9.CrossRefPubMedGoogle Scholar
  51. 51.
    Remerand F, Le Tendre C, Baud A, Couvret C, Pourrat X, Favard L, et al. The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. Anesth Analg. 2009;109(6):1963–71.CrossRefPubMedGoogle Scholar
  52. 52.
    Sveticic G, Farzanegan F, Zmoos P, Zmoos S, Eichenberger U, Curatolo M. Is the combination of morphine with ketamine better than morphine alone for postoperative intravenous patient-controlled analgesia? Anesth Analg. 2008;106(1):287–93 (table of contents).CrossRefPubMedGoogle Scholar
  53. 53.
    Hayes C, Armstrong-Brown A, Burstal R. Perioperative intravenous ketamine infusion for the prevention of persistent post-amputation pain: a randomized, controlled trial. Anaesth Intensive Care. 2004;32(3):330–8.PubMedGoogle Scholar
  54. 54.
    Katz J, Schmid R, Snijdelaar DG, Coderre TJ, McCartney CJ, Wowk A. Pre-emptive analgesia using intravenous fentanyl plus low-dose ketamine for radical prostatectomy under general anesthesia does not produce short-term or long-term reductions in pain or analgesic use. Pain. 2004;110(3):707–18.CrossRefPubMedGoogle Scholar
  55. 55.
    Dullenkopf A, Muller R, Dillmann F, Wiedemeier P, Hegi TR, Gautschi S. An intraoperative pre-incision single dose of intravenous ketamine does not have an effect on postoperative analgesic requirements under clinical conditions. Anaesth Intensive Care. 2009;37(5):753–7.PubMedGoogle Scholar
  56. 56.
    Elia N, Tramer MR. Ketamine and postoperative pain: a quantitative systematic review of randomised trials. Pain. 2005;113(1–2):61–70.CrossRefPubMedGoogle Scholar
  57. 57.
    Schley M, Topfner S, Wiech K, Schaller HE, Konrad CJ, Schmelz M, et al. Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees. Eur J Pain. 2007;11(3):299–308.CrossRefPubMedGoogle Scholar
  58. 58.
    Eisenberg E, Pud D, Koltun L, Loven D. Effect of early administration of the N-methyl-d-aspartate receptor antagonist amantadine on the development of postmastectomy pain syndrome: a prospective pilot study. J Pain. 2007;8(3):223–9.CrossRefPubMedGoogle Scholar
  59. 59.
    Dahl JB, Moiniche S, Kehlet H. Wound infiltration with local anaesthetics for postoperative pain relief. Acta Anaesthesiol Scand. 1994;38(1):7–14.CrossRefPubMedGoogle Scholar
  60. 60.
    Fassoulaki A, Sarantopoulos C, Melemeni A, Hogan Q. Regional block and mexiletine: the effect on pain after cancer breast surgery. Reg Anesth Pain Med. 2001;26(3):223–8.PubMedGoogle Scholar
  61. 61.
    Hollmann MW, Strumper D, Herroeder S, Durieux ME. Receptors, G proteins, and their interactions. Anesthesiology. 2005;103(5):1066–78.CrossRefPubMedGoogle Scholar
  62. 62.
    Sugimoto M, Uchida I, Mashimo T. Local anaesthetics have different mechanisms and sites of action at the recombinant N-methyl-d-aspartate (NMDA) receptors. Br J Pharmacol. 2003;138(5):876–82.CrossRefPubMedCentralPubMedGoogle Scholar
  63. 63.
    Grigoras A, Lee P, Sattar F, Shorten G. Perioperative intravenous lidocaine decreases the incidence of persistent pain after breast surgery. Clin J Pain. 2012;28(7):567–72.CrossRefPubMedGoogle Scholar
  64. 64.
    Fassoulaki A, Patris K, Sarantopoulos C, Hogan Q. The analgesic effect of gabapentin and mexiletine after breast surgery for cancer. Anesth Analg. 2002;95(4):985–91 (table of contents).PubMedGoogle Scholar
  65. 65.
    Karanicolas P, Cleary S, McHardy P, McCluskey S, Sawyer J, Ladak S, et al. Medial open transversus abdominis plane (MOTAP) catheters for analgesia following open liver resection: study protocol for a randomized controlled trial. Trials. 2014;15:241 (241-6215-15-241).CrossRefPubMedCentralPubMedGoogle Scholar
  66. 66.
    Taylor K, Rowbotham MC. Venlafaxine hydrochloride and chronic pain. West J Med. 1996;165(3):147–8.PubMedCentralPubMedGoogle Scholar
  67. 67.
    Moulin D, Boulanger A, Clark AJ, Clarke H, Dao T, Finley GA, et al. Pharmacological management of chronic neuropathic pain: revised consensus statement from the Canadian Pain Society. Pain Res Manag. 2014;19(6):328–35.PubMedCentralPubMedGoogle Scholar
  68. 68.
    Goldstein DJ, Lu Y, Detke MJ, Lee TC, Iyengar S. Duloxetine vs. placebo in patients with painful diabetic neuropathy. Pain. 2005;116(1–2):109–18.CrossRefPubMedGoogle Scholar
  69. 69.
    Yasuda H, Hotta N, Nakao K, Kasuga M, Kashiwagi A, Kawamori R. Superiority of duloxetine to placebo in improving diabetic neuropathic pain: results of a randomized controlled trial in Japan. J Diabetes Investig. 2011;2(2):132–9.CrossRefPubMedCentralPubMedGoogle Scholar
  70. 70.
    Raskin J, Pritchett YL, Wang F, D’Souza DN, Waninger AL, Iyengar S, et al. A double-blind, randomized multicenter trial comparing duloxetine with placebo in the management of diabetic peripheral neuropathic pain. Pain Med. 2005;6(5):346–56.CrossRefPubMedGoogle Scholar
  71. 71.
    Wernicke JF, Pritchett YL, D’Souza DN, Waninger A, Tran P, Iyengar S, et al. A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain. Neurology. 2006;67(8):1411–20.CrossRefPubMedGoogle Scholar
  72. 72.
    Fassoulaki A, Triga A, Melemeni A, Sarantopoulos C. Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. Anesth Analg. 2005;101(5):1427–32.CrossRefPubMedGoogle Scholar
  73. 73.
    Lavand’homme P, De Kock M, Waterloos H. Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery. Anesthesiology. 2005;103(4):813–20.CrossRefPubMedGoogle Scholar
  74. 74.
    Clarke H, Pereira S, Kennedy D, Gilron I, Katz J, Gollish J, et al. Gabapentin decreases morphine consumption and improves functional recovery following total knee arthroplasty. Pain Res Manag. 2009;14(3):217–22.PubMedCentralPubMedGoogle Scholar
  75. 75.
    Horlocker TT, Kopp SL, Pagnano MW, Hebl JR. Analgesia for total hip and knee arthroplasty: a multimodal pathway featuring peripheral nerve block. J Am Acad Orthop Surg. 2006;14(3):126–35.PubMedGoogle Scholar
  76. 76.
    Larson DW, Lovely JK, Cima RR, Dozois EJ, Chua H, Wolff BG, et al. Outcomes after implementation of a multimodal standard care pathway for laparoscopic colorectal surgery. Br J Surg. 2014;101(8):1023–30.CrossRefPubMedGoogle Scholar
  77. 77.
    Humble SR, Dalton AJ, Li L. A systematic review of therapeutic interventions to reduce acute and chronic post-surgical pain after amputation, thoracotomy or mastectomy. Eur J Pain. 2014.Google Scholar
  78. 78.
    Young EE, Lariviere WR, Belfer I. Genetic basis of pain variability: recent advances. J Med Genet. 2012;49(1):1–9.CrossRefPubMedGoogle Scholar
  79. 79.
    Clarke H, Katz J, Flor H, Rietschel M, Diehl SR, Seltzer Z. Genetics of chronic post-surgical pain: a crucial step toward personal pain medicine. Can J Anaesth. 2014.Google Scholar
  80. 80.
    Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, et al. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med. 2012;18(4):595–9.CrossRefPubMedCentralPubMedGoogle Scholar
  81. 81.
    Nissenbaum J, Devor M, Seltzer Z, Gebauer M, Michaelis M, Tal M, et al. Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2. Genome Res. 2010;20(9):1180–90.CrossRefPubMedCentralPubMedGoogle Scholar
  82. 82.
    Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G, et al. Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain. 2010;133(9):2519–27.CrossRefPubMedCentralPubMedGoogle Scholar
  83. 83.
    Trescot AM. Genetics and implications in perioperative analgesia. Best Pract Res Clin Anaesthesiol. 2014;28(2):153–66.CrossRefPubMedGoogle Scholar
  84. 84.
    Yang Z, Yang Z, Arheart KL, Morris R, Zhang Y, Rodriguez Y, et al. CYP2D6 poor metabolizer genotype and smoking predict severe postoperative pain in female patients on arrival to the recovery room. Pain Med. 2012;13(4):604–9.CrossRefPubMedGoogle Scholar
  85. 85.
    Candiotti KA, Yang Z, Rodriguez Y, Crescimone A, Sanchez GC, Takacs P, et al. The impact of CYP2D6 genetic polymorphisms on postoperative morphine consumption. Pain Med. 2009;10(5):799–805.CrossRefPubMedGoogle Scholar
  86. 86.
    Dahl JB, Kehlet H. Preventive analgesia. Curr Opin Anaesthesiol. 2011;24(3):331–8.CrossRefPubMedGoogle Scholar
  87. 87.
    Katz J, McCartney CJ. Current status of preemptive analgesia. Curr Opin Anaesthesiol. 2002;15(4):435–41.CrossRefPubMedGoogle Scholar
  88. 88.
    Katz J, Clarke H. Preventive analgesia and beyond: current status, evidence, and future directions. In: Rice A, Macintyre P, Walker M, Rowbotham D, editors. Clinical pain management. 2nd ed. London: Hodder Arnold; 2008.Google Scholar
  89. 89.
    Tumber PS. Optimizing perioperative analgesia for the complex pain patient: medical and interventional strategies. Can J Anaesth. 2014;61(2):131–40.CrossRefPubMedGoogle Scholar
  90. 90.
    Fisher RB, Johnson QL, Reeves-Viets JL. Pain management mini-series. Part II. Chronic opioid drug therapy: implications for perioperative anesthesia and pain management. Mo Med. 2013;110(3):231–5.PubMedGoogle Scholar
  91. 91.
    Cousins MJ, Power I, Smith G. 1996 Labat lecture: pain–a persistent problem. Reg Anesth Pain Med. 2000;25(1):6–21.PubMedGoogle Scholar
  92. 92.
    Ossipov MH, Dussor GO, Porreca F. Central modulation of pain. J Clin Invest. 2010;120(11):3779–87.CrossRefPubMedCentralPubMedGoogle Scholar
  93. 93.
    Shipton EA. The transition from acute to chronic post surgical pain. Anaesth Intensive Care. 2011;39(5):824–36.PubMedGoogle Scholar
  94. 94.
    Katz J, Asmundson GJ, McRae K, Halket E. Emotional numbing and pain intensity predict the development of pain disability up to one year after lateral thoracotomy. Eur J Pain. 2009;13(8):870–8.CrossRefPubMedGoogle Scholar
  95. 95.
    Page MG, Katz J, Romero Escobar EM, Lutzky-Cohen N, Curtis K, Fuss S, et al. Distinguishing problematic from non-problematic post-surgical pain: a pain trajectory analysis following total knee arthroplasty. Pain. 2015.Google Scholar
  96. 96.
    Burns LC, Ritvo SE, Ferguson MK, Clarke H, Seltzer Z, Katz J. Pain catastrophizing as a risk factor for chronic pain after total knee arthroplasty: a systematic review. J Pain Res. 2015;5(8):21–32.Google Scholar
  97. 97.
    Flor H, Fydrich T, Turk DC. Efficacy of multidisciplinary pain treatment centers: a meta-analytic review. Pain. 1992;49(2):221–30.CrossRefPubMedGoogle Scholar
  98. 98.
    Morley S, Eccleston C, Williams A. Systematic review and meta-analysis of randomized controlled trials of cognitive behaviour therapy and behaviour therapy for chronic pain in adults, excluding headache. Pain. 1999;80(1–2):1–13.CrossRefPubMedGoogle Scholar
  99. 99.
    Vowles KE, McCracken LM. Acceptance and values-based action in chronic pain: a study of treatment effectiveness and process. J Consult Clin Psychol. 2008;76(3):397–407.CrossRefPubMedGoogle Scholar
  100. 100.
    Wetherell JL, Afari N, Rutledge T, Sorrell JT, Stoddard JA, Petkus AJ, et al. A randomized, controlled trial of acceptance and commitment therapy and cognitive-behavioral therapy for chronic pain. Pain. 2011;152(9):2098–107.CrossRefPubMedGoogle Scholar
  101. 101.
    Fernandez MD, Luciano C, Valdivia-Salas S. Impact of acceptance-based nursing intervention on postsurgical recovery: preliminary findings. Span J Psychol. 2012;15(3):1361–70.CrossRefPubMedGoogle Scholar
  102. 102.
    Lin LY, Wang RH. Abdominal surgery, pain and anxiety: preoperative nursing intervention. J Adv Nurs. 2005;51(3):252–60.CrossRefPubMedGoogle Scholar
  103. 103.
    Wicksell RK, Olsson GL. Predicting and preventing chronic postsurgical pain and disability. Anesthesiology. 2010;113(6):1260–1.CrossRefPubMedGoogle Scholar
  104. 104.
    Dworkin RH, Turk DC, Farrar JT, Haythornthwaite JA, Jensen MP, Katz NP, et al. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain. 2005;113(1–2):9–19.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Hance Clarke
    • 1
    • 2
    • 3
  • Michael Poon
    • 1
  • Aliza Weinrib
    • 1
    • 3
  • Rita Katznelson
    • 1
    • 2
    • 3
  • Kirsten Wentlandt
    • 3
    • 5
    • 6
  • Joel Katz
    • 1
    • 2
    • 3
    • 4
  1. 1.Pain Research Unit, Department of Anesthesia and Pain ManagementToronto General HospitalTorontoCanada
  2. 2.Department of AnesthesiaUniversity of TorontoTorontoCanada
  3. 3.Transitional Pain Service, Toronto General HospitalTorontoCanada
  4. 4.Department of PsychologyYork UniversityTorontoCanada
  5. 5.Department of Family and Community MedicineUniversity of TorontoTorontoCanada
  6. 6.Palliative Care, Toronto General HospitalTorontoCanada

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