, Volume 74, Issue 11, pp 1165–1176 | Cite as

Glutamate Receptor Antagonists in the Management of Migraine

  • Kayi Chan
  • Antoinette MaassenVanDenBrinkEmail author
Leading Article


Migraine is a neurovascular disorder that is associated with severe headache and neurologic symptoms. The pathogenesis of migraine is believed to involve trigeminovascular system activation with the primary dysfunction located in brainstem. Glutamate, the major excitatory neurotransmitter in the central nervous system, and its receptors have since long been suggested in migraine pathophysiology. Different preclinical studies have confirmed their potential role in migraine. Moreover, several glutamate receptor modulators have been studied in clinical studies, some with promising results. In this review, we will give an overview of what is known about the role of glutamate in the pathogenesis of migraine, which will be followed by an overview of available efficacy, safety and tolerability data for glutamate receptor inhibitors in clinical development for the treatment of migraine.


Migraine Botulinum Toxin Lamotrigine Topiramate Sumatriptan 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest

Kayi Chan declares that there are no conflicts of interest.

Antoinette MaassenVanDenBrink declares that there are no conflicts of interest. She was supported by the Netherlands Organization for Scientific Research (Vidi grant 917.11.349). No funding was received specifically for writing the review.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of PharmacologyErasmus Medical CenterRotterdamThe Netherlands

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