, Volume 73, Issue 11, pp 1147–1155 | Cite as

Meningococcal Vaccines: Current Issues and Future Strategies

  • Amanda C. Cohn
  • Lee H. Harrison
Review Article


Since the introduction of the first meningococcal conjugate vaccines in 1999, remarkable progress has been made in reducing the morbidity and mortality caused by meningococcal disease. Currently, varying meningococcal conjugate vaccines provide protection against serogroups A, C, Y, and W meningococcal disease. A large impact has been seen after vaccine introduction, particularly in the UK after vaccinating all 1–17 year olds. The introduction of serogroup A conjugate vaccine in the meningitis belt has the potential to control epidemics of disease that disproportionately affect this area of the world. Issues remain that require continued vigilance with disease surveillance and frequent reassessment of vaccine strategies. These issues include duration of protection, potential increases in non-vaccine serogroups, and vaccine safety and potential interference with other routine vaccines. Serogroup B meningococcal vaccines are protein-based vaccines, with the first approved in early 2013. Understanding the potential impact of serogroup B vaccines is critical to developing future meningococcal vaccination strategies.


Conjugate Vaccine Invasive Pneumococcal Disease Booster Dose Meningococcal Disease Vaccine Adverse Event Reporting System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Dr. Cohn has no conflicts of interest and has received no funding for the writing of this manuscript. Dr. Harrison has received research support and lecture fees from Sanofi Pasteur; lecture fees from Novartis Vaccines; and has served as a consultant to GlaxoSmithKline, Merck, Novartis Vaccines, Sanofi Pasteur, and Pfizer. Dr. Harrison’s financial relationships with industry were terminated before he became a voting member of the Advisory Committee on Immunization Practices in July 2012.


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© Springer International Publishing Switzerland 2013

Authors and Affiliations

  1. 1.Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial DiseasesNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and PreventionAtlantaUSA
  2. 2.Infectious Diseases Epidemiology Research Unit, School of Medicine and Graduate School of Public HealthUniversity of PittsburghPittsburghUSA

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